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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TQ0256 | FGFR4-IN-1 | FGFR | |
FGFR4-IN-1 is a potent FGFR4 inhibitor (IC50: 0.7 nM). | |||
T37425 | FGFR4-IN-5 | FGFR4-IN-5 | |
FGFR4-IN-5, a covalent FGFR4 inhibitor, demonstrates potency and selectivity with an IC50 value of 6.5 nM. Exhibiting significant in vivo anti-tumor activity, it is applicable for research in hepatocellular carcinoma [1]... | |||
T79880 | FGFR4-IN-16 | FGFR | |
FGFR4-IN-16 (CY-15-2) is a covalent inhibitor targeting FGFR-4, utilized in cancer research [1]. | |||
T73121 | FGFR4-IN-8 | FGFR | |
FGFR4-IN-8 (Compound 7v) is an ATP-competitive inhibitor that covalently and highly selectively targets both the wild-type and gatekeeper mutant forms of FGFR4. It shows excellent inhibitory potency with IC50s of 0.5 nM ... | |||
T79271 | FGFR4-IN-14 | FGFR | |
FGFR4-IN-14 (Compound 27i) is a selective FGFR4 inhibitor with an IC50 of 2.4 nM, showing potent inhibition of cell proliferation in the V550L and N535K mutant strains. Specifically, it registers IC50 values of 21 nM aga... | |||
T62653 | FGFR-IN-2 | ||
FGFR-IN-2 (compound 1) is a potent inhibitor of FGFR, acting on FGFR1 (IC50: 7.3 nM), FGFR2 (IC50: 4.3 nM), FGFR3 (IC50: 7.6 nM) and FGFR4 (IC50: 11 nM). | |||
T79871 | S6K2-IN-1 | FGFR | |
S6K2-IN-1 (Compound 2) is an inhibitor of S6K2 with an IC50 of 22 nM and also exhibits inhibitory activity against FGFR4 with an IC50 of 216 nM. This compound demonstrates acceptable stability in mouse liver microsomes [... | |||
T79850 | Irpagratinib | ABSK011 | FGFR |
Irpagratinib (ABSK011) is an orally active fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor with specificity for FGFR4, exhibiting an IC50 of less than 10 nM. It effectively inhibits FGFR4 auto-phosphor... | |||
T79257 | FGFR-IN-11 | FGFR | |
FGFR-IN-11 (compound I-5) is an orally active, covalent inhibitor of FGFR, exhibiting IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (FGFR4). This compound demonstrates nanomolar potency in inhi... | |||
T83911 | CYY292 | ||
CYY292 is a chemical compound acting as an inhibitor of PDGFRα, PDGFRβ, FGFR1, -2, and -3, with respective IC50 values of 5.35, 4.6, 28, 28, and 78 nM. It exhibits selectivity over FGFR4 (IC50 > 1,000 nM) while also targ... |